Senior Principal Scientist Chemistry

J&J Family of Companies
July 30, 2022
North Wales, PA
Job Type


Janssen Research and Development, LLC, a member of Johnson and Johnson's Family of Companies, is recruiting for a Senior Principal Scientist, Medicinal Chemistry - Discovery Chemistry, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found.

Janssen Research & Development, LLC, discovers and develops innovative medical solutions to address important unmet medical needs in oncology, immunology, neuroscience, infectious diseases and vaccines, and cardiovascular and metabolic diseases. Please visit for more information.

We are Janssen. Our mission drives us. Our patients inspire us. We collaborate with the world for the health of everyone in it. Thriving on a diverse company culture, celebrating the uniqueness of our employees and committed to inclusion. Proud to be an equal opportunity employer.

Discovery Chemistry is an integral and growing part of the Janssen Therapeutics Discovery (TD) organization, which is committed to the delivery of high-quality drug candidates in partnership with all six Therapeutic Area (TA) discovery organizations. The Discovery Product Development and Supply (DPDS) mission requires deep scientific expertise in multiple disciplines including chemistry, cellular and molecular pharmacology, enzymology, and screening technologies coupled with an ability to work collaboratively with internal and external organizations, including the discovery facing development teams Discovery Product Research (DPR) and Developability.

Building on a strong legacy of success, we are currently recruiting an outstanding individual to join our Spring House, Pennsylvania, based team as Principal Scientist, Medicinal Chemistry, Discovery Chemistry a role that offers tremendous growth opportunity within a dynamic and science-driven organization. Located in suburban Philadelphia, the Janssen Spring House campus sits at the heart of the thriving mid-Atlantic biopharmaceutical belt, offering easy access to some of nations premiere educational, research, and medical centers of excellence.

We are seeking an experienced, highly skilled, and motivated chemist with excellent organic synthesis and medicinal chemistry expertise to shepherd small molecule drug discovery programs and advance them toward the clinic . This position will require the candidate to possess and leverage deep knowledge and capabilities to deliver differentiated clinical candidates to the Janssen product development pipeline within our Disease and Pathway Area Stronghold (DAS and PAS) strategy. Using a mix of internal and external resources, the Principal Scientist will partner with key stakeholders in the TAs and other internal groups, represent medicinal chemistry, lead cross-functional project teams, and be co-responsible for building, managing, and delivering high quality clinical molecules. Candidates with specialized expertise (i.e., peptides, chemical biology, RNA therapeutics, ADCs, HTE, etc.) are encouraged to apply.

Responsibilities of the Senior Principal Scientist will include:

  • As project leader, drive and establish a path forward for medicinal chemistry functions for one or more drug discovery projects, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions

  • Troubleshoots roadblocks independently and collaboratively with colleagues in the identification and delivery of high-quality drug candidates

  • Excellent communication to develop effective partnerships and delegates work effectively to team members

  • Analyze screening data, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support project initiation (or not), compound progression and patent strategies

  • In this role, it essential that the Senior Principal Scientist support or lead cross functional and cross network teams to deliver on Janssen pipeline objectives.

  • Supervise and direct synthetic chemistry activities internally and/or at contract research organizations (CROs)

  • Participate in portfolio and stage-gate reviews, lead the preparation and presentation of dossiers for clinical candidate nomination and compound advancement

  • Participate in shaping and implementing strategies that support medicinal chemistry growth objectives at Janssen

  • Serve as a scientific expert in medicinal chemistry with both internal and external partners and provide recommendations regarding new targets and emerging external opportunities.

  • Ensure optimal interaction/communication and provide updates on project status to TA and Discovery leadership


  • PhD in synthetic or medicinal chemistry with 10+ years of related experience is required

  • Postdoctoral experience is preferred

  • A minimum of 8 years experience in the biopharmaceutical industry with a proven track record of innovative projects and key contributions to clinical candidate selection, preferably as project leader is required

  • Broad experience and proven accomplishments in medicinal chemistry, with operational skills for managing discovery programs at the level of a senior chemist/team leader and a proven track record of delivering clinical candidates is required

  • Expert knowledge of modern methods of synthetic and medicinal chemistry, with ability to conduct medicinal chemistry successfully and simultaneously on multiple projects is required

  • Solid understanding of cellular/molecular biology, biochemistry, disease pharmacology, mechanisms of drug metabolism and molecular toxicology, pharmaco-kinetic and pharmaco-dynamic sciences, and formulations for the in vivo evaluation of drug candidates is required

  • Understanding of hit finding platforms such as DNA-encoded library technologies and protein target degradation strategies is desirable

  • Experience with computational chemistry methods and biophysical techniques such as X-ray crystallography and macromolecular NMR is required

  • Ability to integrate multiple R&D disciplines into a successful strategic project plan is required

  • Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives are required

  • Demonstrated influence, negotiation, and conflict resolution skills, including the ability to succeed within a matrix environment are required. Mentoring talent and contributions towards building a high performing organization are essential

  • Experience in managing project budgets, aligning actions with overall strategy, and supporting business cases for decision-making is preferred

  • Strong track record of scientific contributions including peer reviewed first-author publications, patent applications, and presentations at major national meetings is required

  • Up to 10 - 30% travel both domestically and internationally is required

    At Johnson & Johnson, were on a mission to change the trajectory of health for humanity. That starts by creating the worlds healthiest workforce. Through cutting-edge programs and policies, we empower the physical, mental, emotional, and financial health of our employees and the ones they love. As such, candidates offered employment must show proof of COVID-19 vaccination or secure an approved accommodation prior to the commencement of employment to support the well-being of our employees, their families and the communities in which we live and work.

    For more information on how we support the whole health of our employees throughout their wellness, career and life journey, please visit .

    Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads


Janssen Research & Development, LLC (6084)

Job Function


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