Bench Scientist - Level 3
Job Description: The Senior scientist in Novel Human Genetics-Neuroscience will support a team in the design and execution of scientific studies for the delivery of novel medicines to treat neurodegenerative disorders like Alzheimer’s disease, Parkinson’s disease, and ALS. This role will provide the opportunity to learn and employ cellular models, evaluate drug targets using gene editing and pharmacological tools, and support drug discovery programs.
The successful candidate must be inquisitive, eager to learn new methodologies and concepts, and enjoys doing experiments. This is a lab based role with responsibilities to conduct in vitro and ex vivo experiments in preclinical drug discovery projects using cell lines, rodent brain primary cells as well as human iPSC-derived neurons, astrocytes, and microglia. Familiarity and experience working with basic cell culture, iPSCs, imaging, biochemical techniques, data analysis using graphical software’s is desirable. The successful candidate will be able to learn the methods fast, assumes personal accountability, and keen to learn through experience.
• Maintain iPSCs including quality control assessments
• Differentiate into microglia and other cell types as needed based on SOPs
• Support experiments by providing cell cultures – mono- or bi- or tricultures
• Support efforts in generating gene edits [e.g. CRISPR] and QC in iPSCs
• Culture human iPSC-derived and/or primary rodent neuronal (co-)cultures, standard cell lines etc.
• Clearly document in lab notebooks
• Work collaboratively in the team
• Comply with all standards and practices of data integrity, ethics, and safety.
• Model the Company’s values of patient-focus, respect, transparency, and integrity
• Master of Science degree (Biology, Biotechnology, Neuroscience, Physiology, or related field) with 1-2 years or bachelor’s degree with 5+ years of relevant research experience
• Excellent aseptic technique for cell culture - MUST HAVE
• Basic molecular/ cell biology techniques for discovery research
• Familiarity with using relevant instrumentation
• Written and oral communication skills for documentation and group presentation
• 2+ years pharmaceutical or biotechnology industry research experience working in matrixed drug discovery project teams
• Experience in maintaining iPSC cell factories
• Hands on experience with iPSC cell differentiation into neurons, microglia, and astrocytes
• Basic understanding of gene editing Familiarity with immunoassays (ELISA, FACS).
SRG is an Equal Opportunity Employer - All qualified applicants will receive consideration without regard to race, color, religion, gender, national origin, age, disability, veteran status, or any other factor determined to be unlawful under applicable law.